Walter Scott, Jr. College of Engineering

Graduate Exam Abstract

Gitesh Kulkarni
M.S. Final
Sep 16, 2019, 1:00 pm - 3:00 pm
Scott Building Room 201
Design, Fabrication and Testing of an Electrically Controllable Microfluidic Capillary Valve based on Hydrophobicity
Abstract: Microfluidics is a promising disciple that combines "micro" amount of fluid handling in "micro" sized channels and has found applications in diverse fields such as biotechnology and environmental monitoring. Combination of microfluidics with digital electronics technology has led to creation of Lab-on-a-Chip (LOC) devices that are field-deployable and bought to market in last few decades. In these devices, positioning/transportation of liquids has remained a critical issue. A sample of fluid needs to be acquired from a specimen reservoir and moved to a different reservoir location for analysis. Inexpensive, reliable and straightforward methods to do this transportation makes such instruments low-cost and robust for use in field for variety of purposes. Current ways to do fluid movement require high electric field and hence requiring the use of high voltages (thousands of volts), making the device bulkier. Another approach to use pneumatic pump for droplet movement is also detrimental in making LoC devices portable due to sizes of associated electronics and electrical parts.
This thesis presents the design of a microfluidic valve using capillary action, hydrophobicity, and low voltages (several volts). The use of low voltages brings the "micro" realm to the digital electronics part of LOC. It could lead to better portability, low-power operation of LOC devices, and consequently more adoption in field applications. The design process is based on practical considerations found during experimentation. This method was tested, and results are presented for various biochemical mediums, including KCl, PBS, GMOPS, Cell culture and FBS.
Adviser: Thomas W Chen
Co-Adviser: NA
Non-ECE Member: Brian J Geiss, Microbiology, Immunology and Pathology
Member 3: Edwin K P Chong, ECE
Addional Members: NA
Program of Study:
BIOM 581B5
CS 445
CS 530
ECE 452
ECE 537
ECE 581B2
ECE 581B3