Graduate Exam Abstract

Lang Yang

Ph.D. Final
August 16, 2019, 12:00 pm - 2:00 pm
Scott 201(Atlas studio)

Abstract: Electrochemical analysis has gained a
great deal of attention of late due to its
low-cost, easy-to-perform, and easy-
to-miniaturize, especially in personal
health care where accuracy and
mobility are key factors to bring
diagnostics to patients. According to
data from Centers for Medicare &
Medicaid Services (CMS) in the
US~\cite{expense}, the share of health
expenditure in the US has been kept
growing in the past 3 decades and
reached 17.9% of its overall Gross
Domestic Product till 2016, which is
equivalent to \$10,348 for every
person in the US per year. On the
other hand, health care resources are
often limited not only in rural area but
also appeared in well-developed
countries. The urgent need and the
lack of health resource brings to front
the research interest of Point-of-Care
(PoC) diagnosis devices.
Electrochemical methods have been
largely adopted by chemist and
biologist for their research purposes.
However, several issues exist within
current commercial benchtop
instruments for electrochemical
measurement. First of all, the current
commercial instruments are usually
bulky and do not have handheld
feature for point-of-care applications
and the cost are easily near \$5,000
each or above. Secondly, most of the
instruments do not have good
integration level that can perform
different types of electrochemical
measurements for different
applications. The last but not the least,
the existing generic benchtops
instruments for electrochemical
measurements have complex
operational procedures that require
users to have a sufficient biochemistry
and electrochemistry background to
operate them correctly. The proposed
Crexens\textsuperscript{TM} analyzer
platform is aimed to present an
affordable electrochemical analyzer
while achieving comparable
performance to the existing
commercial instruments, thus, making
general electrochemical measurement
applications accessible to general

Adviser: Dr. Thomas Chen
Co-Adviser: NA
Non-ECE Member: Dr. Stuart Tobet
Member 3: Dr. George Collins
Addional Members: Dr. Jesse Wilson

[1]. Yang, L. and Chen, T.W., 2015, August. A low power 64-point bit-serial fft engine for implantable biomedical applications. In 2015 Euromicro Conference on Digital System Design (pp. 383-389). IEEE.
[2]. Yang, L. and Chen, T., 2016, October. A compact signal generation and acquisition circuit for electrochemical impedance spectroscopy. In 2016 IEEE Biomedical Circuits and Systems Conference (BioCAS) (pp. 260-263). IEEE.
[3]. Yang, L. and Chen, T., 2017, October. A handheld electrochemical sensing platform for point-of-care diagnostic applications. In 2017 IEEE Biomedical Circuits and Systems Conference (BioCAS) (pp. 1-4). IEEE.
[4]. Wang, L., Veselinovic, M., Yang, L., Geiss, B.J., Dandy, D.S. and Chen, T., 2017. A sensitive DNA capacitive biosensor using interdigitated electrodes. Biosensors and Bioelectronics, 87, pp.646-653.
[5]. Tedjo, W., Nejad, J.E., Feeny, R., Yang, L., Henry, C.S., Tobet, S. and Chen, T., 2018. Electrochemical biosensor system using a CMOS microelectrode array provides high spatially and temporally resolved images. Biosensors and Bioelectronics, 114, pp.78-88.

Program of Study:
CS 545
ECE 534
ECE 535
ECE 536
ECE 538
ECE 554
ECE 652
ECE 641