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Graduate Exam Abstract


Lang Yang

Ph.D. Final
August 16, 2019, 12:00 pm - 2:00 pm
Scott 201(Atlas studio)
CREXENS: AN EXPANDABLE GENERAL-PURPOSE ELECTROCHEMICAL ANALYZER

Abstract: Electrochemical analysis has gained a great deal of attention of late due to its low-cost, easy-to-perform, and easy- to-miniaturize, especially in personal health care where accuracy and mobility are key factors to bring diagnostics to patients. According to data from Centers for Medicare & Medicaid Services (CMS) in the US~\cite{expense}, the share of health expenditure in the US has been kept growing in the past 3 decades and reached 17.9% of its overall Gross Domestic Product till 2016, which is equivalent to \$10,348 for every person in the US per year. On the other hand, health care resources are often limited not only in rural area but also appeared in well-developed countries. The urgent need and the lack of health resource brings to front the research interest of Point-of-Care (PoC) diagnosis devices. Electrochemical methods have been largely adopted by chemist and biologist for their research purposes. However, several issues exist within current commercial benchtop instruments for electrochemical measurement. First of all, the current commercial instruments are usually bulky and do not have handheld feature for point-of-care applications and the cost are easily near \$5,000 each or above. Secondly, most of the instruments do not have good integration level that can perform different types of electrochemical measurements for different applications. The last but not the least, the existing generic benchtops instruments for electrochemical measurements have complex operational procedures that require users to have a sufficient biochemistry and electrochemistry background to operate them correctly. The proposed Crexens\textsuperscript{TM} analyzer platform is aimed to present an affordable electrochemical analyzer while achieving comparable performance to the existing commercial instruments, thus, making general electrochemical measurement applications accessible to general public.

Adviser: Dr. Thomas Chen
Co-Adviser: NA
Non-ECE Member: Dr. Stuart Tobet
Member 3: Dr. George Collins
Addional Members: Dr. Jesse Wilson

Publications:
[1]. Yang, L. and Chen, T.W., 2015, August. A low power 64-point bit-serial fft engine for implantable biomedical applications. In 2015 Euromicro Conference on Digital System Design (pp. 383-389). IEEE.
[2]. Yang, L. and Chen, T., 2016, October. A compact signal generation and acquisition circuit for electrochemical impedance spectroscopy. In 2016 IEEE Biomedical Circuits and Systems Conference (BioCAS) (pp. 260-263). IEEE.
[3]. Yang, L. and Chen, T., 2017, October. A handheld electrochemical sensing platform for point-of-care diagnostic applications. In 2017 IEEE Biomedical Circuits and Systems Conference (BioCAS) (pp. 1-4). IEEE.
[4]. Wang, L., Veselinovic, M., Yang, L., Geiss, B.J., Dandy, D.S. and Chen, T., 2017. A sensitive DNA capacitive biosensor using interdigitated electrodes. Biosensors and Bioelectronics, 87, pp.646-653.
[5]. Tedjo, W., Nejad, J.E., Feeny, R., Yang, L., Henry, C.S., Tobet, S. and Chen, T., 2018. Electrochemical biosensor system using a CMOS microelectrode array provides high spatially and temporally resolved images. Biosensors and Bioelectronics, 114, pp.78-88.


Program of Study:
CS 545
ECE 534
ECE 535
ECE 536
ECE 538
ECE 554
ECE 652
ECE 641