Our Research

Our research areas include the biomechanics and mechanobiology of the cardiovascular system, biomechanical mechanisms of cardiovascular diseases, and the development of new diagnosis and treatment of cardiovascular diseases.

Cardiac Biomechanics

Right Ventricle Mechanics

  • Investigate the anisotropic, viscoelastic mechanical properties of the right ventricle in healthy and diseased states
  • Identify the biological determinants responsible for right ventricle viscoelastic mechanical properties
  • Develop constitutive models of myocardium viscoelasticity¬†
High-speed biaxial tester

High-speed biaxial tester

Mechanobiology and Biomechanics Diagram

Right Ventricle Function

  • Investigate the biomechanical mechanisms of right ventricle failure in pulmonary hypertension
  • Explore the impact of ventricular mechanics on organ function
Echo Measurement of Right Ventricle Function

Echo Measurement

Pressure-Volume Measurement of Right Ventricle Function

Pressure-Volume Measurement

Graph of Right Ventricle Function, volume v. pressure

Preclinical Animal Models of Right Ventricle Failure

  • Develop a new animal-specific, graded pulmonary arterial constriction model of right ventricle failure in sheep
  • Use of various rodent models of pulmonary hypertension
  • Investigate the effect of obesity on pulmonary hypertension and right ventricle dysfunction progression

Tissue and Regenerative Engineering

  • Develop an in vitro platform to fabricate biomimetic scaffolds with altered stiffness and anisotropy
  • Investigate the mechanobiology of mesenchymal stromal cells (MSCs) in tissue-specific mechanical environment
  • Explore MSC paracrine effects regulated by mechanical cues
  • Explore and evaluate regenerative therapy for right heart failure

Vascular Biomechanics

  • Investigate the in vivo and ex vivo vascular mechanical properties of blood vessels, including the viscoelasticity and vasoactivity
  • Investigate the changes in vascular biomechanics in various cardiovascular diseases progression