Our Research
Our research areas include the biomechanics and mechanobiology of the cardiovascular system, biomechanical mechanisms of cardiovascular diseases, and the development of new diagnosis and treatment of cardiovascular diseases.
Cardiac Biomechanics
Right Ventricle Mechanics
- Investigate the anisotropic, viscoelastic mechanical properties of the right ventricle in healthy and diseased states
- Identify the biological determinants responsible for right ventricle viscoelastic mechanical properties
- Develop constitutive models of myocardium viscoelasticity
High-speed biaxial tester
Right Ventricle Function
- Investigate the biomechanical mechanisms of right ventricle failure in pulmonary hypertension
- Explore the impact of ventricular mechanics on organ function
Echo Measurement
Pressure-Volume Measurement
Preclinical Animal Models of Right Ventricle Failure
- Develop a new animal-specific, graded pulmonary arterial constriction model of right ventricle failure in sheep
- Use of various rodent models of pulmonary hypertension
- Investigate the effect of obesity on pulmonary hypertension and right ventricle dysfunction progression
Tissue and Regenerative Engineering
- Develop an in vitro platform to fabricate biomimetic scaffolds with altered stiffness and anisotropy
- Investigate the mechanobiology of mesenchymal stromal cells (MSCs) in tissue-specific mechanical environment
- Explore MSC paracrine effects regulated by mechanical cues
- Explore and evaluate regenerative therapy for right heart failure
Vascular Biomechanics
- Investigate the in vivo and ex vivo vascular mechanical properties of blood vessels, including the viscoelasticity and vasoactivity
- Investigate the changes in vascular biomechanics in various cardiovascular diseases progression