Principal Investigator

Christopher Snow Ph.D. [CV]

At CSU, Dr. Snow leads a research group focus on computer-guided protein and DNA engineering, particularly the engineering of crystals. Application areas of interest include bioenergy, synthetic biology, pharmacogenetics, and structural biology. Methods of particular interest include directed evolution, macromolecular crystallography, protein structure prediction, and new algorithms for reliable computational protein engineering. Dr. Christopher Snow joined the Department of Chemical and Biological Engineering in 2011, and has proceeded to join the Department of Biochemistry and Molecular Biology, the Department of Chemistry, the School of Biomedical Engineering, the Cell and Molecular Biology Program, and the School of Advanced Materials Discovery. Dr. Snow received a B.S. degree in Chemistry from MIT in 2001 and his Ph.D. in Biophysics from Stanford University in 2006. As a Howard Hughes fellow at Stanford, Dr. Snow studied the biophysics of protein folding using distributed computing. Before arriving at CSU, Dr. Snow was a Jane Coffin Childs Fellow and a KAUST Research Fellow at Caltech where he developed software for computational protein engineering, designed libraries of cellulase enzymes, and studied protein recombination using high-throughput crystallography.

Abby Ward

Ph.D. Student, Chemistry

Abby joined the Snow Lab in January 2017 and started work characterizing protein crystals with atomic force microscopy and temperature studies. Shortly after, she began working with a team of eight undergraduate students on a project using existing protein and DNA co-crystals as an exandable, designable scaffold. The project has developed to explore co-crystal crosslinking chemistry and designs of original co-crystal scaffolds. She will continue to mentor a team of undergraduate students for the BIOMOD competition for the remainder of her time at CSU. Abby recieved a B.S. degree in Chemistry Health Sciences from UCO and is currently in the Chemistry PhD Program at CSU with a specialty in Chemical Biology.

Gayani Dedduwa-Mudalige

Postdoctoral Fellow

Dr. Gayani Dedduwa-Mudalige in Snow group leads a protein engineering and evolution project for identification of novel protein scaffolds for intracellular imaging applications. Prior to joining Snow lab in 2018, Gayani was a postdoctoral associate in McNaughton lab at CSU, where she developed a Sortase-mediated protein evolution platform for in-cell screening. Gayani obtained her PhD from Wayne State University, Michigan. Her doctoral studies focused on studying kinetics of cisplatin interactions with bacterial ribosomal RNA and identifying platinated RNA products.

Ann Kowalski

Ph.D. Student, Chemical and Biological Engineering

Ann began her PhD at CSU in August 2012 as an NSF IGERT Fellow in Bioenergy. Her work focuses on the use of protein crystals as biotemplating materials for gold nanoparticles and nanorods and other metal nanoarchitectures. She is currently developing methods to image the protein crystal scaffold through small angle x-ray scattering and atomic force microscopy. Ann received her B.S. from Clemson University in Biosystems Engineering with a focus on Environmental Engineering.

Group Alumni

Thaddaus Huber

Ph.D. Student, Chemical and Biological Engineering

Karina Appel

Undergraduate Student, Chemical and Biological Engineering

Lucas Johnson

Ph.D. Student, Chemical and Biological Engineering

Mark Lunt

Masters Student, Chemical and Biological Engineering

Jarad Yost

Undergraduate Student, Chemical and Biological Engineering

Jacob Sebesta

Masters Student, Chemical and Biological Engineering

Matt Baker

Graduate Student, Biomedical Engineering

Joseph Chiavetta

Undergraduate, Chemical and Biological Engineering