PubMed Search

Polarizable Protein Packing
Albert Ng and Christopher Snow Accepted, Journal of Computational Chemistry (2010)

Combinatorial alanine substitution enables rapid optimization of cytochrome P450BM3 for selective hydroxylation of large substrates.
Jared Lewis, Simone Mantovani, Yu Fu, Christopher Snow, Russell Komor, Chi-Huey Wong, and Frances Arnold. Chem. BioChem. (2010), 11, 2502-2505.

Efficient screening of fungal cellobiohydrolase class I enzymes for thermostabilizing sequence blocks by SCHEMA structure-guided recombination
Pete Heinzelman, Russell Komor, Arvind Kanaan, Philip Romero, Xinlin Yu, Shannon Mohler, Christopher Snow and Frances Arnold. Protein Engineering, Design and Selection (2010) dio: 10.1093/protein/gzq063

Non-bulk-like Solvent Behavior in the Ribosome Exit Tunnel.
Del Lucent, Christopher Snow, Colin Aitken, Eric Sorin, Sung-Joo Lee & Vijay S. Pande. Accepted, PLoS Computational Biology.

SCHEMA Recombination of a Fungal Cellulase Uncovers a Single Mutation that Contributes Markedly to Stability
Pete Heinzelman, Christopher D. Snow, Matthew A. Smith, Xinlin Yu, Arbind Kannan, Kevin Boulware, Alan Villalobos, Sridhar Govindarajan, Jeremy Minshull, and Frances H. Arnold. J. Biol. Chem. (2009) 284:26229-26233.

A Family of Thermostable Fungal Cellulases Created by Structure-Guided Recombination
Pete Heinzelman, Christopher D. Snow, Indira Wu, Catherine Nguyen, Alan Villalobos, Sridhar Govindarajanm Jeremy Minshull and Frances H. Arnold. Proc. Natl. Acad. Sci. USA (2009) 106(14):5610-5615.

SHARPEN: Systematic Hierarchical Algorithms for Rotamers and Proteins on an Extended Network
Ilya V. Loksha, James R. Maiolo III, Cheng Hong, Albert Ng, and Christopher D. Snow. Journal of Computational Chemistry (2009) 30(6):999-1005.

Side-chain recognition and gating in the ribosome exit tunnel.
Paula Petrone, Christopher D. Snow, Del Lucent & Vijay S. Pande. Proc. Natl. Acad. Sci. USA (2008) 105(43), 16549-16554.

Evolutionary history of the emergence of a specialized cytochrome P450 propane monooxygenase
Rudi Fasan, Yergalem T. Meharenna, Christopher D. Snow, Thomas L. Poulos, and Frances H. Arnold. Journal of Molecular Biology (2008) 383(5), 1069-1080.

Hunting for predictive computational drug discovery models
Christopher D. Snow. Expert Review of Anti-infective Therapy (2008) 6(3)

A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments.
Yougen Li, Alan D. Drummond, Andrew M. Sawayama, Christopher D. Snow, Jesse D. Bloom, Frances H. Arnold. Nature Biotechnology (2007)

Electric Fields at the Active Site of an Enzyme: Direct Comparison of Experiment with Theory
Ian Suydam, Christopher D. Snow, Vijay S. Pande & Stephen G. Boxer. Science (2006)

Kinetic Definition of Protein Folding Transition State Ensembles and Reaction Coordinates.
Christopher D. Snow, Young Min Rhee, & Vijay S. Pande. Biophysical Journal (2006)

Direct calculation of the binding free energies of FKBP ligands.
Hideaki Fujitani, Yoshiaki Tanida, Masakatsu Ito, Guha Jayachandran, Christopher D. Snow, Michael R. Shirts, Eric J. Sorin, & Vijay S. Pande. Journal of Chemical Physics (2005) 123(8),084108
How well can simulation predict kinetics and thermodynamics of protein folding?
Christopher D. Snow, Eric Sorin, Young Min Rhee, & Vijay S. Pande. Annual Review of Biophysics and Biomolecular Structure

Dimerization of the p53 oligomerization domain: Identification of a folding nucleus by molecular dynamics simulations
Lillian T. Chong, Christopher D. Snow, Young Min Rhee, & Vijay S. Pande. Journal of Molecular Biology (2004) 345(4), 869-78.

Trp zipper folding kinetics by molecular dynamics and temperature-jump spectroscopy
Christopher D. Snow, Linlin Qiu, Deguo Du, Feng Gai, Stephen J. Hagen, & Vijay S. Pande. Proc. Natl. Acad. Sci. USA (2004) 101(12), 4077-4082.
Using path sampling to build better Markovian state models: Predicting the folding rate and mechanism of a tryptophan zipper beta hairpin
Nina Singhal, Christopher D. Snow, and Vijay S. Pande . The Journal of Chemical Physics (2004) 121(1) 415-425.

Absolute comparison of simulated and experimental protein-folding dynamics
Christopher D. Snow, Houbi Nguyen, Vijay S. Pande, Martin Gruebele. Nature AOP, published online 20 October 2002; doi:10.1038/nature01160. Nature (2002) 420(6911), 102-106.

Up Front: Science Behind the Screens
HHMI Bulletin - M. Mitchell Waldrop

hSurface Salt Bridges, Double-Mutant Cycles, and Protein Stability: an Experimental and Computational Analysis of the Interaction of the Asp 23 Side Chain with the N-Terminus of the N-Terminal Domain of the Ribosomal Protein L9.
Donna L. Luisi, Christopher D. Snow, Jo-Jin Lin, Zachary S. Hendsch, Bruce Tidor, Daniel P. Raleigh. Biochemistry (2003) 42(23), 7050-7060.

The Trp Cage: Folding Kinetics and Unfolded State Topology via Molecular Dynamics Simulations.
Christopher D. Snow, Bojan Zagrovic, Vijay S. Pande. J. Am. Chem. Soc. (2002) 124(49), 14548-14549.

Native-like Mean Structure in the Unfolded Ensemble of Small Proteins
Bojan Zagrovic, Christopher D. Snow, Siraj Khaliq, Michael R. Shirts, Vijay S. Pande. J. Mol. Biol. (2002) 323(1), 153-164.
Simulation of folding of a small alpha-helical protein in atomistic detail using worldwide-distributed computing.
Bojan Zagrovic, Christopher D. Snow, Michael R. Shirts, Vijay S. Pande. J. Mol. Biol. (2002) 323(5), 927-937.

Atomistic protein folding simulations on the submillisecond time scale using worldwide distributed computing.
Vijay S. Pande, Ian Baker, Jarrod Chapman, Sidney Elmer, Stefan M. Larson, Young Min Rhee, Michael R. Shirts, Christopher D. Snow, Eric J. Sorin, Bojan Zagrovic. Biopolymers (2002) 68(1): 91-109.

Folding@Home and Genome@Home: Using distributed computing to tackle previously intractable problems in computational biology.
Stefan M. Larson, Christopher D. Snow, Michael R. Shirts, Vijay S. Pande. Computational Genomics, Richard Grant, editor, Horizon Press

RNA binding to the aminoglycoside antibiotic Apramycin
Spring 2002
Professor Puglisi, Stanford, Graduate Student

Simulated Annealing Fragment Monte Carlo: Protein Structure Prediction
Fall 2001 to Winter 2001
Professor Levitt, Stanford, Graduate Student
Preparation for CASP5

Distributed Computing Protein Folding
Spring 2001 to Summer 2001
Professor Pande, Stanford, Visiting Researcher
Collaboration with Professor Gruebele at the University of Illinois
2002 Kollman Satellite Meeting: Biophysical Society

Electrostatic Analysis of NTL9
Spring 2000 to Fall 2001
Professor Tidor, MIT, Undergraduate Researcher
Collaboration with Professor Dan Raleigh at SUNY Stony Brook
2001 Pfizer Undergraduate Fellow Conference

Electrostatic Ranking of Myoglobin Chimera
Fall 1998 to Summer 1999
Professor Tidor, MIT, Undergraduate Researcher
1999 Protein Society Meeting