HEMOCOMPATIBILITY in MEDICAL DEVICES
Bark’s postdoctoral research was supported by a National Institutes of Health (National Heart Lung and Blood Institute) F32 Ruth L. Kirschstein National Research Service Award Individual Postdoctoral Fellowship, “Biomechanical Response of Platelets to Superhydrophobic Surface in Mechanical Heart Valves and Other Blood-Contacting Medical Devices.” Bark investigated the hemodynamic and hemocompatibility characteristics of various options for replacement heart valves: polymeric valves, coated mechanical valves, and textile valves. He showed that the best hemodynamics depend on flexible valves and the properties that define the valves. Hemocompatibility increased for hydrophilic surface designs and for valves coated with superhydrophobic layers. Results are being applied by Bark and collaborators to the development of a number of promising prosthetic valves that overcome the limitations of current FDA-approved devices. These efforts have led to an R01, funded by the National Heart Lung and Blood Institute, where Bark is serving as a co-investigator.
THE BARK LAB
David Bark is an assistant professor of mechanical engineering in the Walter Scott, Jr. College of Engineering at Colorado State University, and also holds an appointment in the School of Biomedical Engineering. Bark and his group conduct research in cardiovascular biomechanics and mechanobiology, with a focus on hemostasis and thrombosis, heart development, and the development of medical devices.
Bark earned his Ph.D. in bioengineering and M.S. in mechanical engineering from the Georgia Institute of Technology, and completed his B.S. in mechanical engineering at the University of Illinois at Urbana/Champaign. Bark’s postgraduate professional experience includes research fellow positions at the University of Canterbury in Christchurch, New Zealand, and the Australian Centre for Blood Diseases at Monash University in Melbourne, Australia; postdoctoral fellow in the Department of Mechanical Engineering at Colorado State University; and postdoctoral fellow in the Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, where he holds an appointment as adjunct assistant professor. His postdoctoral research was supported by a National Institutes of Health (National Heart Lung and Blood Institute) F32 Ruth L. Kirschstein National Research Service Award Individual Postdoctoral Fellowship.