Dr. Salman Khetani

Publications

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  Refereed Journal Articles Top
22 Khetani, S.R., Ballinger, K.R., Berger, D.R., Davidson, M.D., Lin, C., and Ware, B. "Micro-engineered liver tissues for drug testing" Journal of Laboratory Automation pii: 2211068214566939. [Epub ahead of print] (2015) 2015
21 Mitchell, A.M., Stone, A.E.L., Cheng, L., Ballinger, K., Edwards, M., Stoddard, M., Li, H., Golden-Mason, L., Shaw, G.M., Khetani, S.R, and Rosen, H.R. "Transmitted/founder hepatitis C viruses induce cell type- and genotype-specific differences in innate signaling within the liver" mBio (in press) 2015
20 Schwartz, R.E., Fleming, H.E., Khetani, S.R., and Bhatia, S.N. Pluripotent stem cell-derived hepatocyte-like cells. Biotechnology Advances 32(2): 504-513 (2014) 2014
19 Giugliano, S., Golden-Mason, L., Dobrinskikh, E., Stone, A., Kriss, M., Soto-Guiterrez, A., Mitchell, A., Khetani, S.R., Shaw, G.M., Stolz, D., Yamane, D., Lemon, S.M., Gale, M., Shah, V., and Rosen, H.R. "Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cell and release of exosomes, which inhibits viral replication" Gastroenterology 148(2): 392-402.e13 (Epub 2014 Nov 4) 2014
18 Berger, D., Ware, B., Davidson, M., and Khetani, S.R. "Enhancing the functional maturity of iPSC-derived human hepatocytes via controlled presentation of cell-cell interactions in vitro" Hepatology doi: 10.1002/hep.27621. [Epub ahead of print] (2014) 2014
17 Davidson, M.D., Lehrer, M., and Khetani, S.R.. "Hormone and drug-mediated modulation of glucose metabolism in a microscale model of the human liver" Tissue Engineering, Part C Methods [Epub ahead of print] (2014). 2014
16 Khetani, S.R., Kanchagar, C., Krzyzewski, S., Aleo, M., and Will, Y. The Use of Micropatterned Co-cultures to Detect Compounds that Cause Drug induced Liver Injury in Humans. Toxicological Sciences 132(1): 107-117 (2013) 2013
15 Ukairo, O., Kanchagar, C., Moore, A., Shi, J., Gaffney, J., Aoyama, S., Rose, K., Krzyzewski, S., McGeehan, J., Andersen, M.E., Khetani, S.R.*, and LeCluyse, E.L. Long-term Stability of Primary Rat Hepatocytes in Micropatterned Co-cultures. Journal of Biochemical and Molecular Toxicology 27(3): 204-212 (2013) *Corresponding author 2013
14 Chan, T.S., Yu, H., Moore, A., Khetani, S.R. and Tweedie, D. Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac. Drug Metabolism and Disposition 41(12): 2024-1032 (2013) 2013
13 Ukairo, O., McVay, M., Krzyzewski, S., Aoyama, S., Rose, K., Andersen, M.E., Khetani, S.R.*, and LeCluyse, E.L. Bioactivation and Toxicity of Acetaminophen in a Rat Hepatocyte Micropatterned Co-culture System. Journal of Biochemical and Molecular Toxicology 27(10): 471-480 (2013) *Corresponding author 2013
12 Wang, W.W., Khetani, S.R., Krzyzewski, S., Duignan, D.B., and Obach, R.S. "Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites" Drug Metabolism and Disposition 38(10): p1900-1905 (2010) 2010
11 Ploss, A.*, Khetani, S.R.*, Jones, C.T., Syder, A. J., Trehan, K., Gaysinskaya, V.A., Mu, K., Ritola, K. D., Rice, C.M., and Bhatia, S.N. "Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures" Proceedings of the National Academy of Sciences 107(7): p3141- 3145 (2010) *These authors contributed equally to this work 2010
10 Jones, C.T.*, Catanes, M.T., Law, L.M., Khetani, S.R., Syder A.J., Ploss, A., Oh, T.S., Schoggins, J.W., MacDonald, M.R., Bhatia S.N., Rice, C.M. "Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system" Nature Biotechnology 28(2): p167-171 (2010) 2010
9 March, S., Hui, E.E., Underhill G.H., Khetani, S., and Bhatia, S.N. "Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro" Hepatology 50(3): p920-928 (2009) 2009
8 Chen, A.A.*, Khetani, S.R.*, Bhatia, S.N., and Van Vliet, K. J., "Chemomechanical Optimization of an In Vitro Liver Model" Biomaterials 30(6): p1113-1120 (2009) *These authors contributed equally to this work 2009
7 Khetani, S.R., Ranscht, B., and Bhatia, S.N., "T-Cadherin Modulates Hepatocyte Functions In Vitro" FASEB Journal 22(11): p3768-75 (2008) 2008
6 Khetani, S.R., and Bhatia, S.N., "Microscale Human Liver Tissue for Drug Development" Nature Biotechnology 26(1): p120-126 (2007) 2007
5 Allen, J.W., Khetani, S.R., Johnson, R.S., and Bhatia, S.N., "In Vitro Liver Tissue Model Established From Transgenic Mice: Role of HIF-1alpha on Hypoxic Gene Expression" Tissue Engineering 12(11): p3135-3147 (2006) 2006
4 Khetani, S.R., and Bhatia, S.N., "Engineering Tissues for In Vitro Applications" Current Opinion in Biotechnology 17(5): p524-531 (2006) 2006
3 Chen, A.A*., Derfus, A.M*., Khetani, S.R., and Bhatia, S.N., "Quantum Dots to Monitor siRNA Delivery and Improve Gene Silencing." Nucleic Acids Research 33(22): p190 (2005) * These authors contributed equally 2005
2 Allen, J.W., Khetani, S.R., and Bhatia, S.N., "In Vitro Zonation and Toxicity in a Hepatocyte Bioreactor." Toxicological Sciences 84: p110-119 (2004) 2004
1 Khetani, S.R., Szulgit, G., Del Rio, J.A., Barlow, C., and Bhatia, S.N., "Exploring Interactions between Rat Hepatocytes and Nonparenchymal Cells Using Gene Expression Profiling." Hepatology 40(3): p545-554 (2004) 2004
 
  Non-Refereed Journal Articles / Chapters / Proceedings / Transactions Top
15 Underhill, G.H., Khetani, S.R., Chen, A.A., and Bhatia, S.N., "Liver Tissue Engineering", in Principles of Tissue Engineering, Third Edition. R. Lanza, R. Langer, J.P. Vacanti (eds.), Elsevier, p. 707-732 (2007) 2007
14 Underhill, G.H., Felix, J., Allen, J.W., Tsang, V.L., Khetani, S.R., and Bhatia, S.N., "Tissue Engineering of the Liver", in Culture of Cells for Tissue Engineering. G. Vunjak-Novakovic, R.I. Freshney (eds.), John Wiley and Sons (2006) 2006
13 Khetani, S.R., Berger, D., Ware, B.W., and Davidson, M.D. "Long-term Engineered Cultures of iPSC-derived Human Hepatocytes for Disease Modeling and Drug Screening" Hepatology 60 (Supplement S1): 179A (2014) 2014
12 Ukairo,O., McVay, M., Krzyzewski, S., Rose, K., Anderson, M., Khetani, S., and LeCluyse, E. "Bioactivation and Toxicity of Acetaminophen in Rat Primary Hepatocytes Cultured in Micropatterned Co-cultures." Drug Metabolism Reviews 45 (Supplement 1): 150 (2014) 2014
11 McVay, M., Kanchagar, C., Khetani, S.R., and Ukairo, O. "In Vitro Modeling of Cytokine-Drug Interactions Using Micropatterned Co-cultures of Primary Hepatocytes and Kupffer Macrophages." Toxicology Letters 221 (Supplement): S150 (2013) 2013
10 Ukairo, O., McVay, M., Kanchagar, C. and Khetani, S.R. "A Micropatterned Culture with Human Hepatocytes and Kupffer Macrophages For Studying Inflammation-Drug Interactions." Drug Metabolism Reviews 44 (Supplement 1): 108 (2012) 2012
9 Khetani, S.R. "Microscale Engineered Models of the Liver For Drug Development." Drug Metabolism Reviews 43 (Supplement 2): 7 (2011) 2011
8 Chan. T.S., Khetani, S.R., Moore, A., and Yu, H.B. "Accurate Prediction of Hepatic Clearance For Low-Clearance Compounds Using Micropatterned Hepatocyte-Stromal Cell Co-Cultures." Drug Metabolism Reviews 43 (Supplement 2): 48 (2011) 2011
7 Quinn, K., Nakamura, D., Zhang, H. Gauby, S., Lorentzen, C., Goldbach, E., Moore, A., Khetani, S.R., Liang, E., and Sauer, J.M. "Be Careful What you Ask For: Challenges of Predicting Human Clearance For A Low Metabolic Turnover Compound, ELND006." Drug Metabolism Reviews 43 (Supplement 2): 49 (2011) 2011
6 McVay, M., and Khetani, S.R. "Global Gene Expression Changes Induced in Primary Human Hepatocytes by Thiazolidinediones Upon Repeat Dosing of HepatoPac Cultures" Drug Metabolism Reviews 43 (Supplement 2): 115-116 (2011) 2011
5 Aoyama, S., Lambirth, S., and Khetani, S.R. "A Long Term Culture Model For Primary Hepatocytes From Cynomolgus Monkeys" Drug Metabolism Reviews 43 (Supplement 2): 124 (2011) 2011
4 Khetani, S.R., Krzyzewski, S., Moore, A., Gaffney, J., McGeehan, J., Wang, W.W., Duignan, D., and Obach, R.S. "Microscale Engineered Human Liver Model for Investigative Toxicology, Drug Metabolism and Efficacy Assessment." Drug Metabolism Reviews 42 (Supplement 1): 36-37 (2010) 2010
3 Khetani, S.R., Krzyzewski, S.A., Moore, A., Wang, W.W., Duignan, D., and Obach, R.S. "Investigation of Hepatotoxicity and Drug Metabolism In a Microsacle Model of the Human Liver." Hepatology 52 (Supplement): 366A (2010) 2010
2 Khetani, S.R., and Bhatia, S.N. "Development and Characterization of Microscale Models of Rat and Human Livers." Hepatology 46 (Supplement): 773A (2007) 2007
1 Martone, M.E., Peltier, S., Lamont, S., Gupta, A., Ludaescher, B., Khetani, S., Molina, T., and Ellisman, M.H. "Increasing access to tomographic resources: web-based telemicroscopy and database." Microsc. Micronanal. 7 (Suppl 2: Proceedings Microscopy Society of America): 92--93 (2001) 2001
 

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