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Refereed Journal Articles |
Top |
| 22 |
Khetani, S.R., Ballinger, K.R., Berger, D.R., Davidson, M.D., Lin, C., and Ware, B. "Micro-engineered liver tissues for drug testing" Journal of Laboratory Automation pii: 2211068214566939. [Epub ahead of print] (2015) |
2015 |
| 21 |
Mitchell, A.M., Stone, A.E.L., Cheng, L., Ballinger, K., Edwards, M., Stoddard, M., Li, H., Golden-Mason, L., Shaw, G.M., Khetani, S.R, and Rosen, H.R. "Transmitted/founder hepatitis C viruses induce cell type- and genotype-specific differences in innate signaling within the liver" mBio (in press) |
2015 |
| 20 |
Schwartz, R.E., Fleming, H.E., Khetani, S.R., and Bhatia, S.N. Pluripotent stem cell-derived hepatocyte-like cells. Biotechnology Advances 32(2): 504-513 (2014) |
2014 |
| 19 |
Giugliano, S., Golden-Mason, L., Dobrinskikh, E., Stone, A., Kriss, M., Soto-Guiterrez, A., Mitchell, A., Khetani, S.R., Shaw, G.M., Stolz, D., Yamane, D., Lemon, S.M., Gale, M., Shah, V., and Rosen, H.R. "Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cell and release of exosomes, which inhibits viral replication" Gastroenterology 148(2): 392-402.e13 (Epub 2014 Nov 4) |
2014 |
| 18 |
Berger, D., Ware, B., Davidson, M., and Khetani, S.R. "Enhancing the functional maturity of iPSC-derived human hepatocytes via controlled presentation of cell-cell interactions in vitro" Hepatology doi: 10.1002/hep.27621. [Epub ahead of print] (2014) |
2014 |
| 17 |
Davidson, M.D., Lehrer, M., and Khetani, S.R.. "Hormone and drug-mediated modulation of glucose metabolism in a microscale model of the human liver" Tissue Engineering, Part C Methods [Epub ahead of print] (2014). |
2014 |
| 16 |
Khetani, S.R., Kanchagar, C., Krzyzewski, S., Aleo, M., and Will, Y. The Use of Micropatterned Co-cultures to Detect Compounds that Cause Drug induced Liver Injury in Humans. Toxicological Sciences 132(1): 107-117 (2013) |
2013 |
| 15 |
Ukairo, O., Kanchagar, C., Moore, A., Shi, J., Gaffney, J., Aoyama, S., Rose, K., Krzyzewski, S., McGeehan, J., Andersen, M.E., Khetani, S.R.*, and LeCluyse, E.L. Long-term Stability of Primary Rat Hepatocytes in Micropatterned Co-cultures. Journal of Biochemical and Molecular Toxicology 27(3): 204-212 (2013) *Corresponding author |
2013 |
| 14 |
Chan, T.S., Yu, H., Moore, A., Khetani, S.R. and Tweedie, D. Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac. Drug Metabolism and Disposition 41(12): 2024-1032 (2013) |
2013 |
| 13 |
Ukairo, O., McVay, M., Krzyzewski, S., Aoyama, S., Rose, K., Andersen, M.E., Khetani, S.R.*, and LeCluyse, E.L. Bioactivation and Toxicity of Acetaminophen in a Rat Hepatocyte Micropatterned Co-culture System. Journal of Biochemical and Molecular Toxicology 27(10): 471-480 (2013) *Corresponding author |
2013 |
| 12 |
Wang, W.W., Khetani, S.R., Krzyzewski, S., Duignan, D.B., and Obach, R.S. "Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites" Drug Metabolism and Disposition 38(10): p1900-1905 (2010) |
2010 |
| 11 |
Ploss, A.*, Khetani, S.R.*, Jones, C.T., Syder, A. J., Trehan, K., Gaysinskaya, V.A., Mu, K., Ritola, K. D., Rice, C.M., and Bhatia, S.N. "Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures" Proceedings of the National Academy of Sciences 107(7): p3141- 3145 (2010) *These authors contributed equally to this work |
2010 |
| 10 |
Jones, C.T.*, Catanes, M.T., Law, L.M., Khetani, S.R., Syder A.J., Ploss, A., Oh, T.S., Schoggins, J.W., MacDonald, M.R., Bhatia S.N., Rice, C.M. "Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system" Nature Biotechnology 28(2): p167-171 (2010) |
2010 |
| 9 |
March, S., Hui, E.E., Underhill G.H., Khetani, S., and Bhatia, S.N. "Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro" Hepatology 50(3): p920-928 (2009) |
2009 |
| 8 |
Chen, A.A.*, Khetani, S.R.*, Bhatia, S.N., and Van Vliet, K. J., "Chemomechanical Optimization of an In Vitro Liver Model" Biomaterials 30(6): p1113-1120 (2009) *These authors contributed equally to this work |
2009 |
| 7 |
Khetani, S.R., Ranscht, B., and Bhatia, S.N., "T-Cadherin Modulates Hepatocyte Functions In Vitro" FASEB Journal 22(11): p3768-75 (2008) |
2008 |
| 6 |
Khetani, S.R., and Bhatia, S.N., "Microscale Human Liver Tissue for Drug Development" Nature Biotechnology 26(1): p120-126 (2007) |
2007 |
| 5 |
Allen, J.W., Khetani, S.R., Johnson, R.S., and Bhatia, S.N., "In Vitro Liver Tissue Model Established From Transgenic Mice: Role of HIF-1alpha on Hypoxic Gene Expression" Tissue Engineering 12(11): p3135-3147 (2006) |
2006 |
| 4 |
Khetani, S.R., and Bhatia, S.N., "Engineering Tissues for In Vitro Applications" Current Opinion in Biotechnology 17(5): p524-531 (2006) |
2006 |
| 3 |
Chen, A.A*., Derfus, A.M*., Khetani, S.R., and Bhatia, S.N., "Quantum Dots to Monitor siRNA Delivery and Improve Gene Silencing." Nucleic Acids Research 33(22): p190 (2005) * These authors contributed equally |
2005 |
| 2 |
Allen, J.W., Khetani, S.R., and Bhatia, S.N., "In Vitro Zonation and Toxicity in a Hepatocyte Bioreactor." Toxicological Sciences 84: p110-119 (2004) |
2004 |
| 1 |
Khetani, S.R., Szulgit, G., Del Rio, J.A., Barlow, C., and Bhatia, S.N., "Exploring Interactions between Rat Hepatocytes and Nonparenchymal Cells Using Gene Expression Profiling." Hepatology 40(3): p545-554 (2004) |
2004 |
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Non-Refereed Journal Articles / Chapters / Proceedings / Transactions |
Top |
| 15 |
Underhill, G.H., Khetani, S.R., Chen, A.A., and Bhatia, S.N., "Liver Tissue Engineering", in Principles of Tissue Engineering, Third Edition. R. Lanza, R. Langer, J.P. Vacanti (eds.), Elsevier, p. 707-732 (2007) |
2007 |
| 14 |
Underhill, G.H., Felix, J., Allen, J.W., Tsang, V.L., Khetani, S.R., and Bhatia, S.N., "Tissue Engineering of the Liver", in Culture of Cells for Tissue Engineering. G. Vunjak-Novakovic, R.I. Freshney (eds.), John Wiley and Sons (2006) |
2006 |
| 13 |
Khetani, S.R., Berger, D., Ware, B.W., and Davidson, M.D. "Long-term Engineered Cultures of iPSC-derived Human Hepatocytes for Disease Modeling and Drug Screening" Hepatology 60 (Supplement S1): 179A (2014) |
2014 |
| 12 |
Ukairo,O., McVay, M., Krzyzewski, S., Rose, K., Anderson, M., Khetani, S., and LeCluyse, E. "Bioactivation and Toxicity of Acetaminophen in Rat Primary Hepatocytes Cultured in Micropatterned Co-cultures." Drug Metabolism Reviews 45 (Supplement 1): 150 (2014) |
2014 |
| 11 |
McVay, M., Kanchagar, C., Khetani, S.R., and Ukairo, O. "In Vitro Modeling of Cytokine-Drug Interactions Using Micropatterned Co-cultures of Primary Hepatocytes and Kupffer Macrophages." Toxicology Letters 221 (Supplement): S150 (2013) |
2013 |
| 10 |
Ukairo, O., McVay, M., Kanchagar, C. and Khetani, S.R. "A Micropatterned Culture with Human Hepatocytes and Kupffer Macrophages For Studying Inflammation-Drug Interactions." Drug Metabolism Reviews 44 (Supplement 1): 108 (2012) |
2012 |
| 9 |
Khetani, S.R. "Microscale Engineered Models of the Liver For Drug Development." Drug Metabolism Reviews 43 (Supplement 2): 7 (2011) |
2011 |
| 8 |
Chan. T.S., Khetani, S.R., Moore, A., and Yu, H.B. "Accurate Prediction of Hepatic Clearance For Low-Clearance Compounds Using Micropatterned Hepatocyte-Stromal Cell Co-Cultures." Drug Metabolism Reviews 43 (Supplement 2): 48 (2011) |
2011 |
| 7 |
Quinn, K., Nakamura, D., Zhang, H. Gauby, S., Lorentzen, C., Goldbach, E., Moore, A., Khetani, S.R., Liang, E., and Sauer, J.M. "Be Careful What you Ask For: Challenges of Predicting Human Clearance For A Low Metabolic Turnover Compound, ELND006." Drug Metabolism Reviews 43 (Supplement 2): 49 (2011) |
2011 |
| 6 |
McVay, M., and Khetani, S.R. "Global Gene Expression Changes Induced in Primary Human Hepatocytes by Thiazolidinediones Upon Repeat Dosing of HepatoPac Cultures" Drug Metabolism Reviews 43 (Supplement 2): 115-116 (2011) |
2011 |
| 5 |
Aoyama, S., Lambirth, S., and Khetani, S.R. "A Long Term Culture Model For Primary Hepatocytes From Cynomolgus Monkeys" Drug Metabolism Reviews 43 (Supplement 2): 124 (2011) |
2011 |
| 4 |
Khetani, S.R., Krzyzewski, S., Moore, A., Gaffney, J., McGeehan, J., Wang, W.W., Duignan, D., and Obach, R.S. "Microscale Engineered Human Liver Model for Investigative Toxicology, Drug Metabolism and Efficacy Assessment." Drug Metabolism Reviews 42 (Supplement 1): 36-37 (2010) |
2010 |
| 3 |
Khetani, S.R., Krzyzewski, S.A., Moore, A., Wang, W.W., Duignan, D., and Obach, R.S. "Investigation of Hepatotoxicity and Drug Metabolism In a Microsacle Model of the Human Liver." Hepatology 52 (Supplement): 366A (2010) |
2010 |
| 2 |
Khetani, S.R., and Bhatia, S.N. "Development and Characterization of Microscale Models of Rat and Human Livers." Hepatology 46 (Supplement): 773A (2007) |
2007 |
| 1 |
Martone, M.E., Peltier, S., Lamont, S., Gupta, A., Ludaescher, B., Khetani, S., Molina, T., and Ellisman, M.H. "Increasing access to tomographic resources: web-based telemicroscopy and database." Microsc. Micronanal. 7 (Suppl 2: Proceedings Microscopy Society of America): 92--93 (2001) |
2001 |
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