BIOM 421 – Transport Phenomena in Biomedical Engineering
Prerequisites: BMS 300, LIFE 210, CBE 330, CBE 332 or MECH 344 and MECH 102
Lecture: MW 4:15 – 5:30 p.m.
Location: Scott 229
Instructor: Brian Munsky
Office: Scott 354
Office Hours: T/R - 12pm-1pm, Phoenix Design Studio
Grader: Charlie Mitchell
Texts and Resources:
- Basic Transport Phenomena in Biomedical Engineering, 3rd Edition, by R.L. Fournier, Taylor & Francis, 2006.
- Transport Phenomena in Biological Systems, 2nd Edition, by G.A. Truskey, F. Yuan, and D.K. Katz, Pearson Prentice Hall, 2009
- An Introduction to Modeling of Transport Processes, Applications to Biomedical Systems, by A. Datta and V. Rakesh, Cambridge Texts in Biomedical Engineering, 2010. (Good place to look for examples of potential course projects).
- Texts from CBE 210, 332 and 442.
- Additional course materials will be posted on Canvas.
This course is intended for senior undergraduate biomedical engineering students who have already had courses in differential equations, numerical methods, basic cell biology, basic physiology, thermodynamics and transport phenomena. This course discusses in detail engineering models of active and passive mechanisms of momentum and mass transport in mammalian cell organelles, cells, tissues, organ systems, and organisms. Non-Newtonian properties of blood and biological fluids will be described. Mass transport concepts will include diffusion and thermodynamic partitioning at and across biological membranes, ion transport, oxygen transport, and mass transport coupled to biochemical reaction kinetics and reaction equilibria. Biomedical engineering applications of transport phenomena will include topics such as thermal regulation, drug delivery (targeted, controlled, and localized), pharmacokinetic models (for drug distribution and clearance, toxicology, and biomedical imaging), and design of extracorporeal devices such as blood oxygenators, kidney dialyzers, and bioreactors for tissue engineering. The course will emphasize the development and application of numerical methods to study transport problems.
Students who complete this course will be able to:
1. Use equilibrium thermodynamics to describe driving forces for biological processes such as phase equilibria, interactions at mesophase interfaces (e.g. biological membranes), and partitioning across membranes.
2. Apply engineering models of momentum and mass transport, including both analytical and numerical solutions, to phenomena in biological systems such as flow of biological fluids and active transport across membranes.
3. Solve conservation equations that involve coupled biochemical reaction kinetics and transport phenomena.
4. Discriminate among and numerically simulate different pharmacokinetic models including one-compartment and multiple-compartment models for drug and toxin distribution and clearance in organs and organisms.
5. Use computational analyses of transport phenomena and thermodynamics to probe understanding of biological processes and to design and optimize biomedical devices.
Full Syllabus here for currently enrolled students.