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By some estimates, bacterial strains resistant to antibiotics – so-called superbugs – will cause more deaths than cancer by 2050.

Colorado State University biomedical and chemistry researchers are using creative tactics to subvert these superbugs and their mechanisms of invasion. In particular, they’re devising new ways to keep harmful bacteria from forming sticky matrices called biofilms – and to do it without antibiotic drugs.

Researchers in the laboratory of Melissa Reynolds, associate professor in the Department of Chemistry and core faculty in the School of Biomedical Engineering, have created a new material that inhibits biofilm formation of the virulent superbug Pseudomonas aeruginosa. Their material, described in Advanced Functional Materials, could form the basis for a new kind of antibacterial surface that prevents infections and reduces our reliance on antibiotics.

Bella Neufeld, the first author and graduate student who led the research, explained that her passion for finding new ways to fight superbugs is motivated by how adaptive and impenetrable they are, especially when they are allowed to form biofilms. “Biofilms are nasty once they form, and incredibly difficult to get rid of,” Neufeld said.

Reynolds’ research group makes biocompatible devices and materials that resist infection and won’t be rejected by the body. In this most recent work, they’ve designed a material with inherent properties that keep a bacterial film from forming in the first place.

In the lab, they demonstrated an 85 percent reduction in P. aeruginosa biofilm adhesion. They conducted extensive studies showing the reusability of their film. This indicated that its antibacterial properties are driven by something inherent in the material, so its efficacy wouldn’t fade in a clinical setting.

Chitosan is already widely used as a wound dressing and hemostatic agent. Neufeld says the new biomaterial could form new avenues for antibacterial surfaces. For example, the material could be used for a wound dressing that, instead of gauze, would be made of the chitosan matrix.

Read full story here: https://source.colostate.edu/bacterial-biofilms-begone/