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Graduate Exam Abstract


Weina Wang

Ph.D. Preliminary

April 19, 2011, 2pm

Rockwell 36

Single Cancer Cell Detection with Optofluidic Intracavity Spectroscopy


Abstract: The label-free technique of optofluidic intracavity spectroscopy (OFIS) uses light transmitted through a cellular body in a microfluidic optical resonator to distinguish different types of cells by their spectral signature. The preliminary result on cancer cell differentiation and the optical model associated with the experimental results will be presented.

Adviser: Dr. Kevin Lear
Co-Adviser: N/A
Non-ECE Member: Dr. Kenneth Reardon, CBE
Member 3: Dr. Diego Krapf, ECE
Addional Members: Dr. V Chandrasekar, ECE

Publications:
Journal paper: i. H. Shao, W. Wang, S. E. Lana, and K.L. Lear, "Optofluidic intracavity spectroscopy of canine lymphoma and lymphocytes," IEEE Photonics Technology Letters, vol. 20, no. 5-8, pp. 493-495, Mar-Apr, 2008. ii. W. Wang, D.W. Kisker D.H. Thamm, H. Shao, and K. L. Lear, "Optofluidic Intracavity Spectroscopy of Canine Hemangiosarcoma," IEEE Transactions on Biomedical Engineering, DOI: 10.1109/TBME.2010.2045893, in press, 2010. iii. W. Wang, and K. L. Lear, "A cell lens model for transverse modes in optofluidic intracavity spectroscopy," Journal of Selected Topics in Quantum Electronics on Biophotonics - Part 2, DOI: 10.1109/JSTQE.2009.2035363, in press, Jul-Aug, 2010. Conference presentations: i. W. Wang, H. Shao, K. L. Lear, "Lab-on-a-chip Single Particle Dielectrophoretic Traps," American Physical Society, APS March Meeting, March 5-9, 2007. ii. H. Shao, W. Wang, K. L. Lear, "Optofluidic intracavity spectroscopy of single cells in a passive Fabry-Perot resonator," American Physical Society, APS March Meeting, March 5-9, 2007. iii. W. Wang, D.H. Thamm, D.W. Kisker, and K. L. Lear, "Transverse mode analysis of optofluidic intracavity spectroscopy of canine hemangiosarcoma", to be presented at Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications X in Photonics West 2010 (Proceedings of SPIE), vol. 7559, p. 75590C, DOI: 10.1117/12.842142, 2010. iv. Z. Yi, Z. Zhong, K. Reardon, W. Wang, M. Katragadda, K. L. Lear, "A multichannel fiber optic photoluminescence based biosensor", to be presented at Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications X in Photonics West 2010 (Proceedings of SPIE), vol. 7559, p. 75590T, DOI: 10.1117/12.842900, 2010. v. W. Wang, and K. L. Lear, "Simple Transverse Mode Analysis of Cancer Cells in Optofluidic Intracavity," TuV: Imaging and Spectroscopy of Tissue and Cells, 23rd Annual Photonics Society Meeting, Nov 7-11, 2010. vi. W. Wang and K.L. Lear, "A potential individual cell malignancy indicator: focal length", Advanced Biomedical and Clinical Diagnostic Systems IX, a part of the SPIE BiOS: Biomedical Optics Symposium in Photonics West 2011 (SPIE), paper 7890-1, San Francisco, Jan. 24, 2011.


Program of Study:
EE504
EE512
EE525
EE672
BIOM680
N/A
N/A
N/A