Faculty & Staff
Brad Reisfeld
Glover 107
Ph: (970) 491-1019
Fax: (970) 491-7369
Email: brad.reisfeld@colostate.edu
Dr. Reisfeld's Research
Dr. Reisfeld's research interests lie in areas of biological and
biomedical science that are relevant to human health and are interdisciplinary in nature. His focus, at present, is in examining the fate of xenobiotics (foreign compounds, such as drugs and toxicants) in the body. This includes examining the issues of biodistribution, clearance, and especially metabolism as they relate to the formation and elimination of reactive metabolites involved in carcinogenesis and other adverse health effects.
His current projects include (i) developing an approach using computational methods coupled with targeted experimentation for the analysis and prediction of xenobiotic metabolism, (ii) creating computer-assisted methodologies for examining cytochrome P450 isozyme binding of ligands, (iii) using physiologically-based pharmacokinetic and pharmacodynamic modeling, and Bayesian and Monte Carlo analyses to aid in the assessment of risk associated with environmental pollutant exposure and in the optimization of drug regimens for infectious disease treatment, and (iv) using metabolomics technologies as part of a 'systems biology' approach to understand the disposition, toxicology, and pharmacology associated with exposure to xenobiotics.
See the Quantitative and Computational Toxicology Research Group website <http://computox.colostate.edufor more information about Dr. Reisfeld's research.